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Uncertainties in internal doses calculated for mayak workers - A study of 63 cases

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dc.contributor.author Miller G. en
dc.contributor.author Guilmette R. en
dc.contributor.author Bertelli L. en
dc.contributor.author Waters T. en
dc.contributor.author Romanov S.A. en
dc.contributor.author Zaytseva Y.V. en
dc.date.accessioned 2018-10-16T06:53:47Z
dc.date.available 2018-10-16T06:53:47Z
dc.date.issued 2008
dc.identifier.issn 1448420
dc.identifier.uri http://dspace.susu.ru/handle/0001.74/20632
dc.description.abstract This study makes use of 63 cases of Mayak workers exposed to Pu-239 with autopsy data and some late-time urine bioassay data. In addition, air-concentration data-used to construct monthly average values-are available for each case, which provide the time dependence and potential magnitudes of normal inhalation intakes for each case. The purpose of the study is to develop and test Bayesian methods of dose calculation for the Mayak workers. The first part of the study was to quantitatively characterise the uncertainties of the bioassay data. Then, starting with three different published biokinetic models, the data are fit by varying intake and model perturbation parameters, e.g., parameters influencing the lung, thoracic lymph nodes, liver and bone retention. Statistical self-consistency arguments are used to check the measurement uncertainty parameters within the Poisson-lognormal model. The second part of the study is to set up and test Bayesian dose calculations, which use the point determinations of biokinetic parameters from the study cases within a discrete, empirical Bayes approximation. The main conclusion of the study is that these methods are now ready to be applied to the entire Mayak worker population. © The Author 2008. Published by Oxford University Press. All rights reserved. en]
dc.language.iso English
dc.relation.ispartof Radiation Protection Dosimetry en]
dc.subject plutonium 239 en]
dc.subject adult en]
dc.subject article en]
dc.subject autopsy en]
dc.subject Bayes theorem en]
dc.subject case study en]
dc.subject controlled study en]
dc.subject data analysis en]
dc.subject data extraction en]
dc.subject dosimetry en]
dc.subject female en]
dc.subject human en]
dc.subject human tissue en]
dc.subject male en]
dc.subject mathematical model en]
dc.subject occupational exposure en]
dc.subject Poisson distribution en]
dc.subject quantitative analysis en]
dc.subject radiation dose en]
dc.subject radiation exposure en]
dc.subject radiation injury en]
dc.subject radiation measurement en]
dc.subject uncertainty en]
dc.subject urinalysis en]
dc.subject worker en]
dc.subject Administration, Inhalation en]
dc.subject Air Pollutants, Occupational en]
dc.subject Air Pollutants, Radioactive en]
dc.subject Algorithms en]
dc.subject Autopsy en]
dc.subject Bayes Theorem en]
dc.subject Biological Assay en]
dc.subject Body Burden en]
dc.subject Humans en]
dc.subject Models, Statistical en]
dc.subject Occupational Exposure en]
dc.subject Plutonium en]
dc.subject Radiometry en]
dc.subject Tissue Distribution en]
dc.subject Uncertainty en]
dc.title Uncertainties in internal doses calculated for mayak workers - A study of 63 cases en
dc.type Article en]
dc.identifier.doi 10.1093/rpd/ncn181
dc.identifier.scopus https://www.scopus.com/inward/record.uri?eid=2-s2.0-56849096308&doi=10.1093%2frpd%2fncn181&partnerID=40&md5=40941c022e1b1573ae5e0f632c028d69

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